Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.69 |
| ▸ | SRC | P12931 | 4/20 | 0.69 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.69 |
| ▸ | CDK2 | P24941 | 5/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 4/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | CDC7 | O00311 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | IKBKB | O14920 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | CHUK | O15111 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216010 | 0.89 | SYK (0.68) | SYKSRCZAP70CDK2PIK3CG | |
| SCHEMBL14378897 | 0.86 | SRC (0.68) | SYKSRCZAP70CDK2PIK3CG | |
| SCHEMBL14216222 | 0.86 | CDK2 (0.79) | SYKSRCZAP70CDK2PIK3CG | |
| SCHEMBL14216157 | 0.85 | SYK (0.70) | SYKSRCZAP70CDK2PIK3CG | |
| SCHEMBL7468136 | 0.85 | PIK3CG (0.68) | SYKSRCZAP70CDK2PIK3CG | |
| SCHEMBL14216067 | 0.84 | SRC (0.72) | SYKSRCZAP70CDK2EGFR | |
| SCHEMBL14216006 | 0.83 | SYK (0.74) | SYKSRCZAP70CDK2EGFR | |
| SCHEMBL14378874 | 0.83 | ZAP70 (0.67) | SYKSRCZAP70CDK2PIK3CG | |
| SCHEMBL14216079 | 0.83 | CDK2 (0.67) | SYKSRCZAP70CDK2PIK3CG | |
| SCHEMBL14216070 | 0.83 | SRC (0.67) | SYKSRCZAP70CDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |