Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.67 |
| ▸ | ABL1 | P00519 | 7/20 | 0.67 |
| ▸ | BCR | P11274 | 7/20 | 0.67 |
| ▸ | SYK | P43405 | 5/20 | 0.60 |
| ▸ | ZAP70 | P43403 | 4/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | PRKCA | P17252 | 4/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | PRKCH | P24723 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.48 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216072 | 0.90 | SYK (0.67) | SRCABL1BCRSYKZAP70 | |
| SCHEMBL14216060 | 0.90 | SRC (0.64) | SRCABL1BCRSYKZAP70 | |
| SCHEMBL14216061 | 0.88 | SYK (0.61) | SRCABL1BCRSYKZAP70 | |
| SCHEMBL14216028 | 0.84 | SRC (0.64) | SRCABL1BCRSYKZAP70 | |
| SCHEMBL14378939 | 0.83 | SYK (0.60) | SRCABL1BCRSYKZAP70 | |
| SCHEMBL14216065 | 0.83 | SYK (0.69) | SRCSYKZAP70CDK2ROCK1 | |
| SCHEMBL14216222 | 0.82 | CDK2 (0.79) | SRCABL1BCRSYKZAP70 | |
| SCHEMBL14378972 | 0.82 | SYK (0.55) | SRCABL1BCRSYKZAP70 | |
| SCHEMBL1927119 | 0.81 | ABL1 (1.00) | SRCABL1BCRZAP70PRKCA | |
| SCHEMBL14216069 | 0.81 | CDK2 (0.65) | SRCABL1BCRSYKZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |