Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.68 |
| ▸ | SRC | P12931 | 10/20 | 0.68 |
| ▸ | ZAP70 | P43403 | 10/20 | 0.68 |
| ▸ | CDK2 | P24941 | 5/20 | 0.68 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216169 | 0.94 | SYK (0.66) | SYKSRCZAP70CDK2JAK3 | |
| SCHEMBL14378908 | 0.88 | SYK (0.70) | SYKSRCZAP70CDK2JAK3 | |
| SCHEMBL14216162 | 0.87 | SYK (0.69) | SYKSRCZAP70CDK2 | |
| SCHEMBL14216302 | 0.86 | SYK (0.71) | SYKSRCZAP70CDK2JAK2 | |
| SCHEMBL14216161 | 0.86 | SRC (0.67) | SYKSRCZAP70CDK2JAK3 | |
| SCHEMBL14216206 | 0.84 | SYK (0.64) | SYKSRCZAP70CDK2JAK3 | |
| SCHEMBL14216164 | 0.81 | SYK (0.66) | SYKSRCZAP70CDK2JAK2 | |
| SCHEMBL5038586 | 0.81 | SYK (1.00) | SYKSRCZAP70CDK2JAK2 | |
| SCHEMBL14216022 | 0.79 | SYK (0.79) | SYKSRCZAP70CDK2JAK2 | |
| SCHEMBL5037349 | 0.79 | SYK (0.79) | SYKSRCZAP70CDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |