Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.70 |
| ▸ | ZAP70 | P43403 | 13/20 | 0.70 |
| ▸ | SRC | P12931 | 11/20 | 0.70 |
| ▸ | CDK2 | P24941 | 6/20 | 0.70 |
| ▸ | FLT3 | P36888 | 6/20 | 0.51 |
| ▸ | JAK2 | O60674 | 5/20 | 0.47 |
| ▸ | LYN | P07948 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216162 | 0.91 | SYK (0.69) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL14216161 | 0.90 | SRC (0.67) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216166 | 0.88 | SYK (0.68) | SYKZAP70SRCCDK2JAK2 | |
| SCHEMBL14216302 | 0.88 | SYK (0.71) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL14216169 | 0.84 | SYK (0.66) | SYKZAP70SRCCDK2JAK3 | |
| SCHEMBL14216005 | 0.82 | SYK (0.69) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL14216053 | 0.82 | SYK (0.66) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL5038586 | 0.82 | SYK (1.00) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL14216022 | 0.82 | SYK (0.79) | SYKZAP70SRCCDK2FLT3 | |
| SCHEMBL5037349 | 0.82 | SYK (0.79) | SYKZAP70SRCCDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |