Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.72 |
| ▸ | ZAP70 | P43403 | 13/20 | 0.72 |
| ▸ | SRC | P12931 | 11/20 | 0.72 |
| ▸ | CDK2 | P24941 | 7/20 | 0.72 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14216122 | 0.84 | ZAP70 (1.00) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL14216203 | 0.81 | SYK (0.77) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL14216024 | 0.81 | ZAP70 (0.77) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL14216198 | 0.81 | ZAP70 (0.77) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL14216017 | 0.80 | SYK (0.80) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL5043703 | 0.80 | SYK (0.73) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL5034149 | 0.79 | SYK (0.72) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL14216160 | 0.79 | SYK (1.00) | SYKZAP70SRCCDK2CDK4 | |
| SCHEMBL14216081 | 0.79 | ZAP70 (0.88) | SYKZAP70SRCCDK2KDR | |
| SCHEMBL14216274 | 0.78 | SYK (0.77) | SYKZAP70SRCCDK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605946-B1 | THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |
| US-7276502-B2 | Thiazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-02 | — | — | US | disclosed |