Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.66 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.66 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.66 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.66 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | TPMT | P51580 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322445 | 0.89 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL8270539 | 0.84 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL4823365 | 0.84 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL8271319 | 0.84 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL4823369 | 0.84 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL12182752 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DNFE2L2 | |
| SCHEMBL8500731 | 0.83 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4816601 | 0.83 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28111437 | 0.83 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DNFE2L2 | |
| SCHEMBL12182759 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | CELGENE CORPORATION | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114061-A1 | Diphenylethylene compounds and uses thereof | VHL, TNF, PTGES | PDE4A 2547/4885PDE4B 2484/4885PDE4C 2542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.