Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 5/20 | 0.44 |
| ▸ | AR | P10275 | 4/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19957128 | 0.89 | MET (0.52) | EGFRERBB2IMPDH2IMPDH1MET | |
| SCHEMBL14540937 | 0.85 | SRC (0.44) | EGFRERBB2SRCAR | |
| SCHEMBL1895913 | 0.84 | SRC (0.50) | EGFRERBB2SRC | |
| SCHEMBL24009286 | 0.84 | MAP2K1 (0.46) | EGFRERBB2IMPDH2IMPDH1MET | |
| Hydrochloric Acid SCHEMBL6432114 | 0.82 | SRC (0.49) | EGFRERBB2SRC | |
| SCHEMBL1496287 | 0.82 | PDGFRB (0.57) | EGFRSRC | |
| SCHEMBL12503594 | 0.80 | PDGFRB (0.47) | EGFRSRC | |
| SCHEMBL4299967 | 0.80 | SRC (0.52) | EGFRERBB2SRCMAP2K1 | |
| Methane SCHEMBL24557063 | 0.79 | PDGFRB (0.46) | EGFRSRC | |
| SCHEMBL17136805 | 0.78 | SRC (0.50) | EGFRERBB2SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371765-B2 | Quinoline derivatives having VEGF inhibiting activity | ASTRAZENECA AB (SE) | 2008-05-13 | — | — | US | disclosed |