Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074330 | 0.81 | SMN1; SMN2 (0.42) | HTTPOLBITGB1ITGA4ITGB7 | |
| SCHEMBL13995328 | 0.81 | P2RX7 (0.43) | HTTL3MBTL1SMN1; SMN2P2RX7 | |
| SCHEMBL13995321 | 0.76 | CHRM2 (0.59) | HTTITGB1ITGA4ITGB7LMNA | |
| SCHEMBL13965836 | 0.74 | HTT (0.45) | HTTPOLBOPRL1ATML3MBTL1 | |
| SCHEMBL13995329 | 0.72 | CYP1A2 (0.54) | HTTITGB1ITGA4ITGB7LMNA | |
| SCHEMBL13995332 | 0.71 | MEN1 (0.53) | HTTPOLBOPRL1ATML3MBTL1 | |
| SCHEMBL3700809 | 0.70 | KCNH2 (0.49) | HTTPOLBLMNAP2RX7MEN1 | |
| SCHEMBL6078627 | 0.70 | CYP1A2 (0.54) | POLBL3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19125726 | 0.69 | GRIN2D (0.39) | HTTL3MBTL1LMNASMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL6077979 | 0.69 | CYP1A2 (0.56) | POLBL3MBTL1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | disclosed |