Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133385 | 0.81 | APP (0.41) | ROCK1MAPTEGFRNPC1RAB9A | |
| SCHEMBL13538215 | 0.77 | CCR1 (0.45) | ROCK1CYP1A2NOS3NOS1NOS2 | |
| SCHEMBL24110617 | 0.76 | HTR2C (0.40) | ROCK1MAPTHTR2C | |
| SCHEMBL4013641 | 0.74 | MAPT (0.34) | ROCK1MAPTEGFRNPC1RAB9A | |
| SCHEMBL1150503 | 0.74 | FGFR1 (0.44) | ROCK1MAPTEGFRNPC1RAB9A | |
| SCHEMBL23327801 | 0.74 | SLC22A12 (0.41) | MAPTCYP1A2ALDH1A1F2GLA | |
| SCHEMBL29533363 | 0.74 | HTR2C (0.35) | ROCK1MAPTEGFRNPC1RAB9A | |
| SCHEMBL25296103 | 0.74 | HTR2C (0.62) | HTR2C | |
| SCHEMBL24110210 | 0.74 | HTR2C (0.62) | HTR2C | |
| SCHEMBL24110214 | 0.74 | MTNR1A (0.41) | MAPTNPC1RAB9AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371765-B2 | Quinoline derivatives having VEGF inhibiting activity | ASTRAZENECA AB (SE) | 2008-05-13 | — | — | US | disclosed |