Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4153233 | 0.92 | ABCG2 (0.63) | ABCG2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL25022832 | 0.85 | ABCG2 (0.73) | ABCG2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL1180724 | 0.85 | ABCG2 (0.51) | ABCG2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL4150940 | 0.85 | ABCG2 (0.48) | ABCG2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL4150944 | 0.84 | MAOB (0.51) | ABCG2MAPTPPARGMAOBABCB1 | |
| SCHEMBL4250813 | 0.84 | ABCG2 (0.57) | ABCG2KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL7548319 | 0.83 | MAOB (0.48) | ABCG2MAOBABCB1ACHENPC1 | |
| SCHEMBL4167435 | 0.82 | ABCG2 (0.70) | ABCG2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL1422889 | 0.82 | ABCG2 (0.47) | ABCG2KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL117674 | 0.82 | MAOB (0.50) | ABCG2PPARGMAOBABCB1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297127-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | AxoGlia Therapeutics S.A. (LU) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009130253-A1 | CHROMENONE DERIVATIVES USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | AXOGLIA THERAPEUTICS S.A. (LU) | 2009-10-29 | — | — | WO | disclosed |