Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 7/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378984 | 0.91 | GPR183 (0.55) | GPR183TDP1KDM4EHPGDTSHR | |
| SCHEMBL14190909 | 0.91 | GPR183 (0.55) | GPR183TDP1KDM4EHPGDTSHR | |
| SCHEMBL14190947 | 0.89 | GPR183 (0.48) | GPR183TDP1KMT2AMEN1HPGD | |
| SCHEMBL4384367 | 0.89 | GPR183 (0.48) | GPR183TDP1KMT2AMEN1HPGD | |
| SCHEMBL4381584 | 0.84 | SMN1; SMN2 (0.47) | GPR183TDP1KDM4EHPGDTSHR | |
| SCHEMBL13636007 | 0.84 | SMN1; SMN2 (0.47) | GPR183TDP1KDM4EHPGDTSHR | |
| SCHEMBL4381901 | 0.83 | SMN1; SMN2 (0.46) | GPR183KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL14190929 | 0.83 | SMN1; SMN2 (0.46) | GPR183KDM4EHPGDTSHRSMN1; SMN2 | |
| SCHEMBL4380528 | 0.83 | ALDH1A1 (0.48) | GPR183KMT2AKDM4EHPGDTSHR | |
| SCHEMBL13636356 | 0.83 | ALDH1A1 (0.48) | GPR183KMT2AKDM4EHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | GPR183 264/4885TDP1 3908/4885KMT2A 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.