SCHEMBL14218593

SCHEMBL14218593

COc1ccc(F)cc1C(C)(C)CC(O)(CNc1cc(C)cc2c1cnn2-c1cccc(C(=O)NC(CC(N)=O)C(N)=O)c1)C(F)(F)F

nearest known ligand 0.71

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 20/20 0.71
PGR P06401 2/20 0.46
NR3C2 P08235 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3171678 1.00 NR3C1 (0.71) NR3C1PGRNR3C2
SCHEMBL3171691 0.96 NR3C1 (0.70) NR3C1PGRNR3C2
SCHEMBL1774567 0.94 NR3C1 (0.72) NR3C1PGRNR3C2
SCHEMBL3172915 0.94 NR3C1 (0.72) NR3C1PGRNR3C2
SCHEMBL1775469 0.94 NR3C1 (0.72) NR3C1PGRNR3C2
SCHEMBL3171414 0.94 NR3C1 (0.70) NR3C1PGRNR3C2
SCHEMBL14218568 0.94 NR3C1 (0.70) NR3C1PGRNR3C2
SCHEMBL1775742 0.93 NR3C1 (0.73) NR3C1PGRNR3C2
SCHEMBL1775810 0.93 NR3C1 (0.73) NR3C1PGRNR3C2
SCHEMBL3171421 0.92 NR3C1 (0.69) NR3C1PGRNR3C2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008043788-A2 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2008-04-17 WO disclosed