Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.64 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8292832 | 0.84 | AXL (0.66) | AXLCYP2A6KEAP1ALDH1A1KDM4E | |
| SCHEMBL16756015 | 0.81 | AXL (0.62) | AXLCYP2A6KEAP1ALDH1A1KDM4E | |
| SCHEMBL12327788 | 0.81 | AXL (0.62) | AXLCYP2A6KEAP1ALDH1A1KDM4E | |
| SCHEMBL22300369 | 0.80 | AXL (0.65) | AXLCYP2A6KEAP1ALDH1A1KDM4E | |
| SCHEMBL13344896 | 0.80 | AXL (0.60) | AXLCYP2A6KEAP1ALDH1A1KDM4E | |
| SCHEMBL16756134 | 0.79 | AXL (0.58) | AXLCYP2A6KEAP1ALDH1A1KDM4E | |
| SCHEMBL30235444 | 0.78 | AXL (1.00) | AXLCYP2A6KEAP1ALDH1A1KDM4E | |
| SCHEMBL74023 | 0.78 | AXL (1.00) | AXLCYP2A6KEAP1ALDH1A1KDM4E | |
| SCHEMBL13344928 | 0.78 | PDGFRB (0.60) | AXLCYP2A6KEAP1ALDH1A1KDM4E | |
| SCHEMBL5123477 | 0.78 | KDM4E (0.64) | AXLALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008047883-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-04-24 | — | — | WO | disclosed |