Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.36 |
| ▸ | LCK | P06239 | 8/20 | 0.36 |
| ▸ | LYN | P07948 | 8/20 | 0.36 |
| ▸ | SRC | P12931 | 8/20 | 0.36 |
| ▸ | INSR | P06213 | 7/20 | 0.36 |
| ▸ | HCK | P08631 | 7/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3588170 | 0.93 | KDR (0.42) | KDRLCKLYNSRCINSR | |
| SCHEMBL3590408 | 0.88 | BRAF (0.47) | KDRLCKLYNSRCINSR | |
| SCHEMBL3589488 | 0.88 | BRAF (0.47) | KDRLCKLYNSRCINSR | |
| SCHEMBL3597510 | 0.83 | BRAF (0.42) | KDRLCKLYNSRCINSR | |
| SCHEMBL3583837 | 0.83 | LCK (0.44) | KDRLCKLYNSRCINSR | |
| SCHEMBL14218755 | 0.82 | CSF1R (0.43) | KDRLCKLYNSRCINSR | |
| SCHEMBL14219020 | 0.81 | BRAF (0.45) | KDRLCKLYNSRCINSR | |
| SCHEMBL3589393 | 0.81 | LCK (0.48) | KDRLCKLYNSRCINSR | |
| SCHEMBL3590706 | 0.81 | CSF1R (0.47) | KDRLCKLYNSRCINSR | |
| SCHEMBL9928651 | 0.81 | LCK (0.43) | KDRLCKLYNSRCINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |