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Sugi Predict / Compounds / SCHEMBL3590706

SCHEMBL3590706

SCHEMBL3590706

CCN1CCN(Cc2cc(NC(=O)Nc3ccc(C)c(Nc4cc(C)nn4-c4cc(NC)ncn4)c3)cc(C(F)(F)F)c2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 2/20 0.47
▸ BRAF P15056 13/20 0.46
▸ KDR P35968 5/20 0.46
▸ RET P07949 3/20 0.46
▸ HCK P08631 3/20 0.46
▸ MAPK14 Q16539 3/20 0.46
▸ MAP3K7 O43318 2/20 0.46
▸ FES P07332 2/20 0.46
▸ FER P16591 2/20 0.46
▸ MAP4K2 Q12851 2/20 0.46
▸ DDR2 Q16832 2/20 0.46
▸ INSR P06213 2/20 0.46
▸ LCK P06239 2/20 0.46
▸ LYN P07948 2/20 0.46
▸ SRC P12931 2/20 0.46
▸ MKNK1 Q9BUB5 2/20 0.46
▸ MKNK2 Q9HBH9 2/20 0.46
▸ TNNI3K Q59H18 2/20 0.46
▸ STK25 O00506 1/20 0.46
▸ CIT O14578 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3589848 0.94 BRAF (0.49) BRAFKDRMAPK14TNNI3K
SCHEMBL3591101 0.91 BRAF (0.54) BRAFHCKMAPK14MAP3K7FES
SCHEMBL3592320 0.90 KDR (0.49) CSF1RBRAFKDRRETHCK
SCHEMBL3018391 0.89 CSF1R (0.47) CSF1RBRAFKDRRETHCK
SCHEMBL3588170 0.88 KDR (0.42) BRAFKDRHCKMAPK14INSR
SCHEMBL3586278 0.85 CSF1R (0.51) CSF1RBRAF
SCHEMBL3585833 0.85 CSF1R (0.51) CSF1RBRAFKDRHCKINSR
SCHEMBL3583692 0.85 BRAF (0.61) BRAF
SCHEMBL14218840 0.85 BRAF (0.50) CSF1RBRAF
SCHEMBL3587792 0.84 CSF1R (0.51) CSF1RBRAFKDRHCKMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8202876-B2 Compounds and compositions as protein kinase inhibitors IRM LLC (BM) 2012-06-19 — — US claimed
US-20100029605-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2010-02-04 — — US claimed
EP-2057146-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2009-05-13 — — EP claimed
WO-2008042639-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2008-04-10 — — WO claimed
US-8202876-B2 Compounds and compositions as protein kinase inhibitors IRM LLC (BM) 2012-06-19 — — US disclosed
US-8202876-B2 Compounds and compositions as protein kinase inhibitors IRM LLC (BM) 2012-06-19 — — US disclosed
US-20100029605-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2010-02-04 — — US disclosed
US-20100029605-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2010-02-04 — — US disclosed
EP-2057146-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2009-05-13 — — EP disclosed
WO-2008042639-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2008-04-10 — — WO disclosed
WO-2008042639-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS IRM LLC (BM) 2008-04-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100029605-A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS FYN, ABL2, LCK CSF1R 476/4885BRAF 11/4885KDR 13/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.