Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.52 |
| ▸ | RAF1 | P04049 | 4/20 | 0.47 |
| ▸ | ARAF | P10398 | 4/20 | 0.47 |
| ▸ | INSR | P06213 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | LYN | P07948 | 3/20 | 0.41 |
| ▸ | HCK | P08631 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3597698 | 0.93 | BRAF (0.55) | BRAFRAF1ARAFINSRLCK | |
| SCHEMBL3594600 | 0.80 | BRAF (0.60) | BRAFRAF1ARAFKDR | |
| SCHEMBL3580497 | 0.79 | BRAF (0.60) | BRAFRAF1ARAFKDR | |
| SCHEMBL3589071 | 0.77 | BRAF (0.64) | BRAFRAF1ARAF | |
| SCHEMBL3584690 | 0.76 | LCK (0.64) | BRAFINSRLCKLYNHCK | |
| SCHEMBL3596608 | 0.76 | LCK (0.49) | BRAFRAF1ARAFINSRLCK | |
| SCHEMBL3583251 | 0.76 | BRAF (0.55) | BRAFRAF1ARAFKDR | |
| SCHEMBL14218753 | 0.76 | KDR (0.36) | BRAFRAF1INSRLCKLYN | |
| SCHEMBL9970921 | 0.73 | BRAF (0.51) | BRAFRAF1ARAFINSRLCK | |
| SCHEMBL3580748 | 0.73 | BRAF (0.51) | BRAFRAF1ARAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |