Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 18/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 18/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 18/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6683916 | 0.88 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4852240 | 0.85 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL14294145 | 0.84 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4859070 | 0.83 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL14294638 | 0.83 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL4861470 | 0.78 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11CCNA2 | |
| SCHEMBL4227024 | 0.74 | MAPK13 (0.66) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14219128 | 0.71 | USP2 (0.35) | MAPK14 | |
| SCHEMBL4858007 | 0.71 | MAPK13 (0.47) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6204650 | 0.70 | MAPK13 (0.49) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |