Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859291 | 0.86 | USP2 (0.39) | USP2MAPK14SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4850650 | 0.85 | USP2 (0.36) | USP2MAPK14SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4853567 | 0.81 | USP2 (0.41) | USP2MAPK14SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14219125 | 0.73 | HTR2C (0.38) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL14219129 | 0.71 | MAPK14 (0.41) | MAPK14 | |
| SCHEMBL2891578 | 0.69 | LMNA (0.42) | USP2MAPK14SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14219124 | 0.69 | SMN1; SMN2 (0.40) | USP2SMN1; SMN2ALDH1A1MAPTPOLB | |
| SCHEMBL14219127 | 0.69 | SMN1; SMN2 (0.40) | USP2SMN1; SMN2ALDH1A1MAPTPOLB | |
| SCHEMBL14294141 | 0.68 | SMN1; SMN2 (0.36) | USP2SMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL6202498 | 0.63 | SCN9A (0.39) | SMN1; SMN2ALDH1A1LMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |