Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 15/20 | 0.44 |
| ▸ | CX3CR1 | P49238 | 12/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212314 | 0.85 | CXCR2 (0.60) | CXCR2CX3CR1ADORA1 | |
| SCHEMBL215491 | 0.84 | CXCR2 (0.53) | CXCR2CX3CR1ADORA1 | |
| SCHEMBL215490 | 0.84 | CXCR2 (0.53) | CXCR2CX3CR1ADORA1 | |
| SCHEMBL12022742 | 0.84 | CXCR2 (0.53) | CXCR2CX3CR1ADORA1 | |
| SCHEMBL14219237 | 0.83 | CXCR2 (0.53) | CXCR2CX3CR1ADORA1 | |
| SCHEMBL5435212 | 0.78 | CXCR2 (0.53) | CXCR2CX3CR1TLR8TLR7ADORA1 | |
| SCHEMBL5434517 | 0.75 | CXCR2 (0.79) | CXCR2CX3CR1 | |
| SCHEMBL214257 | 0.72 | CXCR2 (0.66) | CXCR2CX3CR1ADORA1 | |
| SCHEMBL5235885 | 0.70 | CX3CR1 (0.60) | CXCR2CX3CR1ADORA1 | |
| SCHEMBL212592 | 0.70 | CX3CR1 (0.60) | CXCR2CX3CR1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039138-A1 | NOVEL 5, 7-DISUBSTITUTED [1, 3 ] THIAZOLO [4, 5-D] PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | WO | disclosed |