SCHEMBL14219554

SCHEMBL14219554

C[C@@H](Cc1ccc(-c2ccc(CCc3ccc(F)c(F)c3)cc2)cc1)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.40
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39
POLB P06746 1/20 0.39
SLC2A1 P11166 1/20 0.37
SIGMAR1 Q99720 4/20 0.36
ACP3 P15309 1/20 0.36
KCNH2 Q12809 1/20 0.36
ADRB1 P08588 1/20 0.35
ADRB3 P13945 1/20 0.35
TAAR1 Q96RJ0 2/20 0.35
FFAR1 O14842 1/20 0.35
CYP17A1 P05093 1/20 0.35
CYP11B1 P15538 1/20 0.35
CYP11B2 P19099 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14219895 1.00 PDPK1 (0.40) PDPK1ESR1ESR2POLBSLC2A1
SCHEMBL14219429 0.90 CYP17A1 (0.44) PDPK1ESR1ESR2ACP3KCNH2
SCHEMBL14219896 0.88 SIGMAR1 (0.40) ESR1ESR2POLBSLC2A1SIGMAR1
SCHEMBL14219565 0.88 SIGMAR1 (0.40) ESR1ESR2POLBSLC2A1SIGMAR1
SCHEMBL14219586 0.86 SLC2A1 (0.38) ESR1ESR2POLBSLC2A1SIGMAR1
SCHEMBL14219455 0.86 ESR1 (0.44) ESR1ESR2POLBSLC2A1SIGMAR1
SCHEMBL14219555 0.85 SIGMAR1 (0.39) ESR1ESR2POLBSIGMAR1ADRB1
SCHEMBL14219901 0.85 SIGMAR1 (0.39) ESR1ESR2POLBSIGMAR1ADRB1
SCHEMBL14219885 0.85 POLB (0.51) ESR1ESR2POLBSIGMAR1ACP3
SCHEMBL14219563 0.85 POLB (0.51) ESR1ESR2POLBSIGMAR1ACP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1650285-B1 Liquid crystal composition containing an optically active compound and liquid crystal electro-optical element SEIMI CHEM KK (JP) 2008-04-30 EP disclosed