Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219627 | 0.89 | MAP2K1 (0.43) | DHODHKMT2APTGS2MAP2K1CHRNA7 | |
| SCHEMBL14223201 | 0.89 | MEN1 (0.40) | DHODHKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL14219742 | 0.88 | MEN1 (0.43) | DHODHKMT2AMEN1TDP1MAP2K1 | |
| SCHEMBL14219715 | 0.88 | PTGS2 (0.41) | DHODHKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL14223057 | 0.87 | MAP2K1 (0.41) | DHODHKMT2AMEN1TDP1MAP2K1 | |
| SCHEMBL14219648 | 0.87 | MEN1 (0.39) | DHODHKMT2AMEN1TDP1PTGS2 | |
| SCHEMBL14220160 | 0.86 | MAP2K1 (0.49) | KMT2AMEN1TDP1MAP2K1 | |
| SCHEMBL14219738 | 0.86 | MEN1 (0.42) | DHODHKMT2AMEN1TDP1MAP2K1 | |
| SCHEMBL14219743 | 0.86 | MEN1 (0.42) | DHODHKMT2AMEN1TDP1MAP2K1 | |
| SCHEMBL14219812 | 0.85 | DHODH (0.51) | DHODHMAP2K1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |