Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219707 | 1.00 | MAP2K1 (0.51) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14219651 | 0.91 | MAP2K1 (0.49) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14223036 | 0.91 | MAP2K1 (0.55) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14219745 | 0.91 | MAP2K1 (0.49) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14219694 | 0.91 | MAP2K1 (0.62) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14219748 | 0.89 | MAP2K1 (0.62) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14222546 | 0.89 | MAP2K1 (0.62) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14220148 | 0.85 | MAP2K1 (0.55) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14219633 | 0.85 | MAP2K1 (0.55) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 | |
| SCHEMBL14223026 | 0.85 | MAP2K1 (0.49) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |