Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.55 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14219633 | 1.00 | MAP2K1 (0.55) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14220182 | 0.91 | MAP2K1 (0.66) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14220145 | 0.91 | MAP2K1 (0.66) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14223029 | 0.91 | MAP2K1 (0.54) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14219637 | 0.91 | MAP2K1 (0.54) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14219854 | 0.91 | MAP2K1 (0.51) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14220149 | 0.91 | MAP2K1 (0.51) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14219741 | 0.90 | MAP2K1 (0.67) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14220107 | 0.90 | MAP2K1 (0.67) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 | |
| SCHEMBL14219636 | 0.85 | MAP2K1 (0.51) | MAP2K1MAP2K2BRAFMAPK1MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |