Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 10/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.38 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14222851 | 0.91 | MAP2K1 (0.42) | PTGS2MAP2K1DHODHMAP2K2RAF1 | |
| SCHEMBL14219715 | 0.90 | PTGS2 (0.41) | PTGS2MAP2K1DHODHPTGESCHRNA7 | |
| SCHEMBL14219627 | 0.88 | MAP2K1 (0.43) | PTGS2MAP2K1DHODHMAP2K2RAF1 | |
| SCHEMBL14220150 | 0.85 | MAP2K1 (0.48) | MAP2K1DHODHMAP2K2RAF1PDGFRB | |
| SCHEMBL14219611 | 0.84 | MAP2K1 (0.62) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL14219721 | 0.84 | MAP2K1 (0.47) | MAP2K1DHODHMAP2K2RAF1PDGFRB | |
| SCHEMBL14220109 | 0.83 | MAP2K1 (0.46) | MAP2K1DHODHMAP2K2RAF1PDGFRB | |
| SCHEMBL14219608 | 0.82 | DHODH (0.54) | MAP2K1DHODHMAP2K2 | |
| SCHEMBL14219628 | 0.81 | MAP2K1 (0.60) | MAP2K1MAP2K2RAF1PDGFRBCSNK2A2 | |
| SCHEMBL14219613 | 0.81 | MAP2K1 (0.58) | MAP2K1MAP2K2MAPK1BRAFMAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |