Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.74 |
| ▸ | DUSP22 | Q9NRW4 | 1/20 | 0.74 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | CASP3 | P42574 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.69 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.69 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.65 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.65 |
| ▸ | ACP1 | P24666 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28687393 | 0.83 | NLRP3 (1.00) | PTPN1DUSP22NLRP3MEN1POLB | |
| SCHEMBL28687390 | 0.83 | NLRP3 (1.00) | PTPN1DUSP22NLRP3MEN1POLB | |
| SCHEMBL4125637 | 0.83 | PTPN1 (0.67) | PTPN1DUSP22NLRP3MEN1POLB | |
| SCHEMBL4125640 | 0.83 | PTPN1 (0.67) | PTPN1DUSP22NLRP3MEN1POLB | |
| SCHEMBL23001307 | 0.81 | NLRP3 (1.00) | PTPN1DUSP22NLRP3MEN1KMT2A | |
| SCHEMBL29365020 | 0.81 | NLRP3 (1.00) | PTPN1DUSP22NLRP3MEN1KMT2A | |
| SCHEMBL22469940 | 0.81 | NLRP3 (1.00) | PTPN1DUSP22NLRP3MEN1KMT2A | |
| SCHEMBL22469941 | 0.81 | NLRP3 (1.00) | PTPN1DUSP22NLRP3MEN1KMT2A | |
| SCHEMBL5459723 | 0.80 | MEN1 (0.87) | PTPN1DUSP22NLRP3MEN1POLB | |
| SCHEMBL5459720 | 0.80 | MEN1 (0.87) | PTPN1DUSP22NLRP3MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1916249-A1 | 3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(thio)oxo-2-(thio)oxo-azolidin-5-ylidene derivatives as antibacterial agents | LEK Pharmaceuticals D.D. (SI) | 2008-04-30 | — | — | EP | disclosed |
| WO-2008043733-A1 | 3- (BENZO [D] [1,3] DIOXOL-5-YLMETHYL) -4- (THIO) OXO-2- (THIO) OXO-AZOLIDIN-5-YLIDENE DERIVATIVES AS ANTIBACTERIAL AGENTS | LEK PHARMACEUTICAL D.D. (SI) | 2008-04-17 | — | — | WO | disclosed |