Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27355270 | 0.91 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT | |
| Carbamic Acid SCHEMBL15653675 | 0.91 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL231151 | 0.87 | — | — | |
| Methyl Alcohol SCHEMBL27521170 | 0.85 | — | — | |
| Formaldehyde SCHEMBL21580185 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL5399914 | 0.85 | — | — | |
| SCHEMBL3568544 | 0.85 | — | — | |
| SCHEMBL31078271 | 0.85 | — | — | |
| SCHEMBL6930011 | 0.85 | — | — | |
| SCHEMBL27853921 | 0.80 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297130-B1 | NEW HETEROAROMATIC AMIDES AND THIOAMIDES AS PEST CONTROL AGENTS | BAYER CROPSCIENCE AG (DE) | 2014-09-17 | — | — | EP | disclosed |
| EP-2730569-A1 | New amides and thioamides as pest control agents | Bayer CropScience AG (DE) | 2014-05-14 | — | — | EP | disclosed |
| EP-2730568-A1 | NEW HETEROAROMATIC AMIDES AND THIOAMIDES AS PEST CONTROL AGENTS | Bayer CropScience AG (DE) | 2014-05-14 | — | — | EP | disclosed |
| EP-2725022-A1 | New amides as pest control agents | Bayer CropScience AG (DE) | 2014-04-30 | — | — | EP | disclosed |
| EP-2725023-A1 | New heteroaromatic amides as pest control agents | Bayer CropScience AG (DE) | 2014-04-30 | — | — | EP | disclosed |
| EP-2725021-A1 | New heteroaromatic thioamides as pest control agents | Bayer CropScience AG (DE) | 2014-04-30 | — | — | EP | disclosed |
| EP-2725020-A1 | New heteroaromatic amides and thioamides as pest control agents | Bayer CropScience AG (DE) | 2014-04-30 | — | — | EP | disclosed |
| EP-2297130-A1 | NOVEL HETEROAROMATIC AMIDES AND THIOAMIDES AS PESTICIDES | Bayer CropScience AG (DE) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009149858-A1 | NOVEL HETEROAROMATIC AMIDES AND THIOAMIDES AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2009-12-17 | — | — | WO | disclosed |