Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.35 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5320954 | 1.00 | EPHX1 (0.47) | EPHX1KCNH2MAPK1OPRK1POLB | |
| SCHEMBL1778461 | 1.00 | EPHX1 (0.47) | EPHX1KCNH2MAPK1OPRK1POLB | |
| Hydrochloric Acid SCHEMBL17560597 | 0.98 | EPHX1 (0.45) | EPHX1KCNH2MAPK1OPRK1POLB | |
| Hydrochloric Acid SCHEMBL17560406 | 0.98 | EPHX1 (0.45) | EPHX1KCNH2MAPK1OPRK1POLB | |
| Hydrochloric Acid SCHEMBL17560408 | 0.98 | EPHX1 (0.45) | EPHX1KCNH2MAPK1OPRK1POLB | |
| SCHEMBL27714012 | 0.89 | MAPK1 (0.55) | EPHX1MAPK1OPRK1TSHRPARP1 | |
| SCHEMBL965984 | 0.89 | MAPK1 (0.55) | EPHX1MAPK1OPRK1TSHRPARP1 | |
| SCHEMBL965310 | 0.88 | EPHX1 (0.61) | EPHX1POLBGNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL17560419 | 0.87 | MAPK1 (0.54) | EPHX1MAPK1OPRK1TSHRPARP1 | |
| Hydrochloric Acid SCHEMBL17560443 | 0.87 | MAPK1 (0.54) | EPHX1MAPK1OPRK1TSHRPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117886814-A | PD-1/PD-L1 small molecule inhibitor and application thereof in medicines | 广东东阳光药业股份有限公司 | 2024-04-16 | — | — | CN | disclosed |
| WO-2023133217-A1 | 2-(INDAZOL-5-YL)-6-(PIPERIDIN-4-YL)-1,7-NAPHTHYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES | REMIX THERAPEUTICS INC. (US) | 2023-07-13 | — | — | WO | disclosed |
| US-11339165-B2 | Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV) | Janssen Sciences Ireland Unlimited Company (IE) | 2022-05-24 | — | — | US | disclosed |
| US-11254676-B2 | Pyrazole derivative compound and use thereof | HANMI PHARM. CO., LTD. (KR) | 2022-02-22 | — | — | US | disclosed |
| US-20210009591-A1 | PYRAZOLE DERIVATIVE COMPOUND AND USE THEREOF | HANMI PHARM. CO., LTD. (KR) | 2021-01-14 | — | — | US | disclosed |
| US-20200361942-A1 | PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | Janssen Sciences Ireland Unlimited Company (IE) | 2020-11-19 | — | — | US | disclosed |
| EP-3681877-A1 | PYRAZOLE DERIVATIVE COMPOUND AND USE THEREOF | Hanmi Pharm. Co., Ltd. (KR) | 2020-07-22 | — | — | EP | disclosed |
| WO-2019054766-A1 | PYRAZOLE DERIVATIVE COMPOUND AND USE THEREOF | HANMI PHARM. CO., LTD. (KR) | 2019-03-21 | — | — | WO | disclosed |
| CN-103987707-B | The base heterocyclic radical benzamide compound of pyrazoles 4 and application method | 霍夫曼-拉罗奇有限公司 | 2017-11-07 | — | — | CN | disclosed |
| CN-103167867-B | Solid dispersion containing apoptosis-inducing medicament | ABBVIE 公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-104926810-A | Pyrrolopyridines As Kinase Inhibitors | ARRAY BIOPHARMA INC | 2015-09-23 | — | — | CN | disclosed |
| CN-102089307-B | Pyrrolopyridines as kinase inhibitors | ARRAY BIOPHARMA INC | 2015-07-01 | — | — | CN | disclosed |
| CN-104349777-A | Compounds for the treatment of spinal muscular atrophy | PTC THERAPEUTICS INC | 2015-02-11 | — | — | CN | disclosed |
| CN-102933572-B | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | HOFFMANN LA ROCHE | 2015-01-07 | — | — | CN | disclosed |
| CN-103987707-A | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | HOFFMANN LA ROCHE | 2014-08-13 | — | — | CN | disclosed |
| CN-103167867-A | Solid dispersions containing an apoptosis-inducing agent | ABBOTT LAB | 2013-06-19 | — | — | CN | disclosed |
| CN-103153993-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | ABBOTT LAB | 2013-06-12 | — | — | CN | disclosed |
| CN-102933572-A | Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use | HOFFMANN LA ROCHE | 2013-02-13 | — | — | CN | disclosed |
| WO-2008041090-A1 | MALANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONIST PYRIDINONES | PFIZER LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |
| US-20080085884-A1 | Melanin Concentrating Hormone Receptor-1 Antagonist Pyridinones | PFIZER INC | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009591-A1 | PYRAZOLE DERIVATIVE COMPOUND AND USE THEREOF | KDM1A, KDM3A, KDM1B | EPHX1 2528/4885KCNH2 1602/4885MAPK1 417/4885 |
| US-20200361942-A1 | PYRAZOLOPYRIMIDINES HAVING ACTIVITY AGAINST THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | RRP15, MAVS, ACE | EPHX1 2081/4885KCNH2 1988/4885MAPK1 1783/4885 |
| US-20080085884-A1 | Melanin Concentrating Hormone Receptor-1 Antagonist Pyridinones | MCHR1, MCHR2, MC1R | EPHX1 941/4885KCNH2 3042/4885MAPK1 665/4885 |
| US-11339165-B2 | Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV) | RRP15, MAVS, ACE | EPHX1 2081/4885KCNH2 1988/4885MAPK1 1783/4885 |
| US-11254676-B2 | Pyrazole derivative compound and use thereof | KDM1A, KDM3A, KDM1B | EPHX1 2528/4885KCNH2 1602/4885MAPK1 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.