Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | CFTR | P13569 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14172583 | 0.94 | MAPT (0.47) | TP53MAPTKDM4EUSP2HTT | |
| SCHEMBL14222750 | 0.86 | TP53 (0.45) | TP53MAPTKDM4EUSP2HTT | |
| SCHEMBL14223146 | 0.83 | ALDH1A1 (0.47) | TP53MAPTKDM4EUSP2HTT | |
| SCHEMBL14172573 | 0.82 | MAPT (0.49) | TP53MAPTKDM4EUSP2HTT | |
| SCHEMBL14172571 | 0.81 | ALDH1A1 (0.46) | TP53MAPTKDM4EUSP2HTT | |
| SCHEMBL14172810 | 0.81 | MAPT (0.47) | TP53MAPTKDM4EUSP2HTT | |
| SCHEMBL14222426 | 0.81 | KDM4E (0.48) | TP53MAPTKDM4EUSP2HTT | |
| SCHEMBL14172578 | 0.80 | ALDH1A1 (0.47) | TP53MAPTKDM4EUSP2HTT | |
| SCHEMBL14172527 | 0.79 | MAPT (0.46) | TP53MAPTKDM4EUSP2HTT | |
| SCHEMBL12796187 | 0.78 | GAA (0.44) | TP53MAPTKDM4EUSP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039520-A2 | FUSED RING COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2008-04-03 | — | — | WO | disclosed |