Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14172589 | 0.89 | GAA (0.46) | GAAMAPTTP53KMT2AMEN1 | |
| SCHEMBL14172529 | 0.88 | ALDH1A1 (0.44) | GAAMAPTTP53KMT2AMEN1 | |
| SCHEMBL14172518 | 0.87 | MAPT (0.54) | GAAMAPTTP53KMT2AMEN1 | |
| SCHEMBL14172531 | 0.86 | ALDH1A1 (0.51) | GAAMAPTTP53KMT2AMEN1 | |
| SCHEMBL14172590 | 0.85 | ALDH1A1 (0.42) | GAAMAPTTP53KMT2AMEN1 | |
| SCHEMBL14222994 | 0.85 | ALDH1A1 (0.42) | GAAMAPTTP53KMT2AMEN1 | |
| SCHEMBL14223146 | 0.84 | ALDH1A1 (0.47) | GAAMAPTTP53KMT2AMEN1 | |
| SCHEMBL14222424 | 0.83 | KDM4E (0.49) | GAAMAPTTP53KMT2AMEN1 | |
| SCHEMBL12796226 | 0.82 | ALDH1A1 (0.44) | GAAMAPTTP53KMT2AMEN1 | |
| SCHEMBL14172538 | 0.82 | ALDH1A1 (0.44) | GAAMAPTTP53KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039520-A2 | FUSED RING COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2008-04-03 | — | — | WO | disclosed |