Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214530 | 0.89 | HRH3 (0.49) | MAPK1LMNAHIF1AALDH1A1ABL1 | |
| SCHEMBL214297 | 0.84 | EPHX2 (0.44) | ALDH1A1SMN1; SMN2KDM4EMET | |
| SCHEMBL216122 | 0.83 | EPHX2 (0.43) | MAPK1LMNAHIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL213580 | 0.82 | LMNA (0.47) | MAPK1LMNAHIF1AALDH1A1ABL1 | |
| SCHEMBL213876 | 0.80 | EPHX2 (0.42) | MEN1KMT2AMAPT | |
| SCHEMBL2735344 | 0.80 | NPC1 (0.52) | MAPK1LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL215460 | 0.79 | LMNA (0.46) | MAPK1LMNAHIF1AABL1SMN1; SMN2 | |
| SCHEMBL3992127 | 0.79 | HRH2 (0.41) | KDM4EMETHSD17B10 | |
| SCHEMBL214860 | 0.79 | LMNA (0.45) | MAPK1LMNAHIF1AABL1SMN1; SMN2 | |
| SCHEMBL2735389 | 0.79 | LMNA (0.45) | MAPK1LMNAHIF1AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |