Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826753 | 0.86 | CHRNA7 (0.45) | KCNH2GHSRCHRNA7KDM4EHSD17B10 | |
| SCHEMBL8251025 | 0.83 | CNR2 (0.50) | KCNH2GHSRCHRNA7KDM4EHSD17B10 | |
| SCHEMBL4818315 | 0.83 | GHSR (0.46) | KCNH2GHSRCHRNA7KDM4EHSD17B10 | |
| SCHEMBL4825563 | 0.82 | CHRNA7 (0.46) | KCNH2GHSRCHRNA7KDM4EHSD17B10 | |
| SCHEMBL4822790 | 0.82 | DRD3 (0.41) | KCNH2GHSRCHRNA7KDM4EHSD17B10 | |
| SCHEMBL4826885 | 0.82 | SMN1; SMN2 (0.48) | KCNH2GHSRCHRNA7KDM4EHSD17B10 | |
| SCHEMBL4823808 | 0.81 | GHSR (0.47) | KCNH2GHSRCHRNA7KDM4EHSD17B10 | |
| SCHEMBL4826756 | 0.81 | CHRNA7 (0.47) | KCNH2GHSRCHRNA7KDM4EHSD17B10 | |
| SCHEMBL4817264 | 0.81 | GHSR (0.46) | KCNH2GHSRCHRNA7HSD17B10ALOX15 | |
| SCHEMBL4822735 | 0.81 | GHSR (0.47) | KCNH2GHSRCHRNA7KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358373-B2 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC (US) | 2008-04-15 | — | — | US | disclosed |