Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13462278 | 0.87 | PTGDR2 (0.57) | MAPTTHRBPTGDR2RXFP1KMT2A | |
| SCHEMBL5769289 | 0.85 | PTGDR2 (0.60) | MAPTTHRBPTGDR2RXFP1TP53 | |
| SCHEMBL4849772 | 0.84 | PTGDR2 (0.58) | MAPTTHRBPTGDR2RXFP1TP53 | |
| SCHEMBL5871817 | 0.80 | MAPT (0.61) | MAPTTHRBPTGDR2RXFP1TP53 | |
| SCHEMBL4852699 | 0.78 | PTGDR2 (0.58) | MAPTTHRBPTGDR2RXFP1TP53 | |
| SCHEMBL4851291 | 0.77 | MAPT (0.58) | MAPTTHRBPTGDR2RXFP1TP53 | |
| SCHEMBL4848876 | 0.77 | CNR2 (0.80) | RXFP1ALDH1A1LMNACNR2 | |
| SCHEMBL7651126 | 0.77 | MAPT (0.72) | MAPTTHRBPTGDR2RXFP1TP53 | |
| SCHEMBL1523317 | 0.76 | MAPT (0.59) | MAPTTHRBPTGDR2RXFP1TP53 | |
| SCHEMBL6531213 | 0.76 | MAPT (0.49) | MAPTTHRBPTGDR2RXFP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361760-B2 | Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases | AVANIR PHARMACEUTICALS (US) | 2008-04-22 | — | — | US | disclosed |