Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | THRB | P10828 | 3/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655267 | 0.90 | MAPT (0.69) | MAPTTHRBRXFP1TP53PTGDR2 | |
| SCHEMBL7652274 | 0.85 | P2RX4 (0.61) | MAPTTHRBRXFP1TP53MEN1 | |
| SCHEMBL7653389 | 0.81 | P2RX4 (0.60) | MAPTTHRBRXFP1TP53MEN1 | |
| SCHEMBL7652923 | 0.81 | P2RX4 (0.58) | MAPTTHRBRXFP1TP53MEN1 | |
| SCHEMBL7651132 | 0.77 | MAPT (0.50) | MAPTTHRBRXFP1MEN1KMT2A | |
| SCHEMBL14224040 | 0.77 | MAPT (0.60) | MAPTTHRBRXFP1TP53PTGDR2 | |
| SCHEMBL1523317 | 0.76 | MAPT (0.59) | MAPTTHRBRXFP1TP53PTGDR2 | |
| SCHEMBL27840298 | 0.76 | P2RX4 (0.62) | MAPTTHRBRXFP1PTGDR2MEN1 | |
| SCHEMBL5871817 | 0.75 | MAPT (0.61) | MAPTTHRBRXFP1TP53PTGDR2 | |
| SCHEMBL4851291 | 0.75 | MAPT (0.58) | MAPTTHRBRXFP1TP53PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |