Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14195965 | 0.93 | GSK3B (0.53) | GSK3BABL1EGFRBCRSRC | |
| SCHEMBL14224271 | 0.91 | ABL1 (0.46) | GSK3BABL1EGFRBCRSRC | |
| SCHEMBL14224269 | 0.91 | ABL1 (0.51) | GSK3BABL1EGFRBCRSRC | |
| SCHEMBL14196002 | 0.88 | GSK3B (0.44) | GSK3BABL1EGFRBCRSRC | |
| SCHEMBL14195970 | 0.85 | PIK3CG (0.49) | GSK3BABL1EGFRBCRSRC | |
| SCHEMBL14224138 | 0.85 | SYK (0.47) | GSK3BABL1EGFRBCRSRC | |
| SCHEMBL14196034 | 0.84 | ABL1 (0.47) | GSK3BABL1EGFRBCRSRC | |
| SCHEMBL14196028 | 0.84 | ABL1 (0.45) | GSK3BABL1EGFRBCRSRC | |
| SCHEMBL14224130 | 0.83 | SYK (0.51) | GSK3BABL1EGFRBCRSRC | |
| SCHEMBL14224457 | 0.83 | SYK (0.51) | GSK3BABL1EGFRBCRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |