Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | BCR | P11274 | 3/20 | 0.46 |
| ▸ | PRKCA | P17252 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 5/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224138 | 0.94 | SYK (0.47) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14224457 | 0.92 | SYK (0.51) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14196041 | 0.92 | SYK (0.47) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14195955 | 0.92 | ABL1 (0.53) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14224080 | 0.91 | GSK3B (0.47) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14196034 | 0.91 | ABL1 (0.47) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14195970 | 0.91 | PIK3CG (0.49) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14224130 | 0.89 | SYK (0.51) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14196040 | 0.89 | SYK (0.47) | ABL1BCRPRKCASRCPRKCD | |
| SCHEMBL14196028 | 0.88 | ABL1 (0.45) | ABL1BCRPRKCASRCPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |