SCHEMBL14224295

SCHEMBL14224295

CN(C)C(=O)n1nc(C(C)(C)C)c(C#N)c1N=Nc1c(O)n(-c2ccccc2)n(-c2ccccc2)c1=O

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.36
MDM2 Q00987 1/20 0.36
MAPT P10636 5/20 0.35
KDM4E B2RXH2 4/20 0.35
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
HPGD P15428 2/20 0.32
LMNA P02545 1/20 0.32
PSMD14 O00487 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
TSHR P16473 1/20 0.31
MAPK1 P28482 1/20 0.31
ALDH1A1 P00352 2/20 0.31
GAA P10253 1/20 0.31
CTSL P07711 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14231295 0.84
SCHEMBL13996972 0.82 MAPT (0.35) TP53MDM2MAPTKDM4EKMT2A
SCHEMBL14227890 0.77 KDM4E (0.36) TP53MDM2MAPTKDM4EKMT2A
SCHEMBL14227814 0.77 L3MBTL1 (0.30) L3MBTL1
SCHEMBL10106251 0.77 MAPT (0.38) TP53MDM2MAPTKDM4EKMT2A
SCHEMBL13997022 0.77 MAPT (0.38) TP53MDM2MAPTKDM4EKMT2A
SCHEMBL13996968 0.76 MAPT (0.35) MAPTKDM4EKMT2AMEN1L3MBTL1
SCHEMBL14224284 0.70
SCHEMBL14001829 0.69
SCHEMBL13997027 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080081284-A1 OPTICAL INFORMATION RECORDING MEDIUM FUJIFILM CORPORATION (JP) 2008-04-03 US disclosed
US-20080081285-A1 OPTICAL INFORMATION RECORDING MEDUM AND AZO-METAL COMPLEX DYE FUJIFILM CORPORATION (JP) 2008-04-03 US disclosed