Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 12/20 | 0.54 |
| ▸ | BCR | P11274 | 10/20 | 0.54 |
| ▸ | SRC | P12931 | 4/20 | 0.54 |
| ▸ | PRKCA | P17252 | 4/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | PRKACB | P22694 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224452 | 0.91 | ABL1 (0.50) | KITABL1BCRSRCPRKCA | |
| SCHEMBL14195964 | 0.89 | ABL1 (0.56) | KITABL1BCRSRCPRKCA | |
| SCHEMBL14224269 | 0.86 | ABL1 (0.51) | KITABL1BCRSRCPRKCA | |
| SCHEMBL14195955 | 0.85 | ABL1 (0.53) | KITABL1BCRSRCPRKCA | |
| SCHEMBL14196017 | 0.84 | ABL1 (0.56) | KITABL1BCRSRCPRKCA | |
| SCHEMBL14224137 | 0.84 | ABL1 (0.66) | ABL1BCRSRCPRKCAPRKCD | |
| SCHEMBL14196025 | 0.83 | ABL1 (0.54) | KITABL1BCRSRCPRKCA | |
| SCHEMBL14195984 | 0.82 | GSK3B (0.48) | KITABL1BCRSRCPRKCA | |
| SCHEMBL14196005 | 0.82 | KIT (0.42) | KITABL1BCRSRCPRKCA | |
| SCHEMBL14195963 | 0.82 | PIK3CG (0.48) | KITABL1BCRSRCPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |