Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | NEK4 | P51957 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.49 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.49 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224780 | 0.85 | KMT2A (0.47) | RIPK1MEN1KMT2APHGDHALDH1A1 | |
| SCHEMBL31037006 | 0.84 | MAPK1 (0.46) | MAPK1RIPK1MEN1KMT2APHGDH | |
| SCHEMBL29751787 | 0.84 | MAPK1 (0.46) | MAPK1RIPK1MEN1KMT2APHGDH | |
| SCHEMBL16901655 | 0.84 | MAPK1 (0.46) | MAPK1RIPK1MEN1KMT2APHGDH | |
| SCHEMBL14224493 | 0.81 | TSHR (0.54) | MAPK1PRKACAGSK3AGSK3BTSHR | |
| SCHEMBL14224656 | 0.81 | TSHR (0.54) | MAPK1PRKACAGSK3AGSK3BTSHR | |
| SCHEMBL14197094 | 0.79 | MAPK1 (0.49) | MAPK1ROCK2RPS6KA5MAP4K4PRKACA | |
| SCHEMBL14224547 | 0.77 | RIPK1 (0.62) | MAPK1ROCK2RPS6KA5MAP4K4PRKACA | |
| SCHEMBL14224491 | 0.77 | RIPK1 (0.62) | MAPK1ROCK2RPS6KA5MAP4K4PRKACA | |
| SCHEMBL29676252 | 0.76 | MAPK1 (0.41) | MAPK1ROCK2ROCK1RIPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354919-B2 | Isoxazole compositions useful as inhibitors of ERK | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-08 | — | — | US | disclosed |