Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26814143 | 0.86 | CYP1A2 (0.62) | CXCR2KMT2AMEN1GAASMN1; SMN2 | |
| SCHEMBL11418838 | 0.85 | MEN1 (0.64) | KMT2AMEN1GAANPC1RAB9A | |
| SCHEMBL6836163 | 0.84 | CXCR2 (0.57) | CXCR2KMT2AMEN1GAANPC1 | |
| SCHEMBL11413181 | 0.83 | CYP1A2 (0.46) | CXCR2KMT2AMEN1GAANPC1 | |
| SCHEMBL4345348 | 0.83 | EPHX2 (0.56) | CXCR2KMT2AMEN1L3MBTL1 | |
| SCHEMBL8600374 | 0.82 | EPHX2 (0.58) | CXCR2KMT2AMEN1L3MBTL1 | |
| SCHEMBL4669116 | 0.82 | GAA (0.44) | CXCR2KMT2AMEN1GAANPC1 | |
| SCHEMBL11428917 | 0.82 | PKM (0.49) | KMT2AMEN1GAANPC1RAB9A | |
| SCHEMBL11428857 | 0.82 | GAA (0.56) | KMT2AMEN1GAANPC1RAB9A | |
| SCHEMBL18029398 | 0.81 | CYP1A2 (0.62) | KMT2AMEN1GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354919-B2 | Isoxazole compositions useful as inhibitors of ERK | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-08 | — | — | US | disclosed |