Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 1/20 | 0.59 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.59 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399870 | 1.00 | GNAI3 (0.59) | GNAI3GNAO1GNAI1KCNH2MTNR1A | |
| SCHEMBL13460003 | 0.90 | GNAI3 (0.49) | GNAI3GNAO1GNAI1KCNH2MTNR1A | |
| SCHEMBL20758976 | 0.90 | GNAI3 (0.49) | GNAI3GNAO1GNAI1KCNH2MTNR1A | |
| SCHEMBL11981666 | 0.89 | GNAI3 (0.73) | GNAI3GNAO1GNAI1MTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7423752 | 0.87 | GNAI3 (0.76) | GNAI3GNAO1GNAI1MTNR1AMTNR1B | |
| SCHEMBL3869700 | 0.87 | GNAI3 (0.80) | GNAI3GNAO1GNAI1EPHX1SMN1; SMN2 | |
| SCHEMBL3871100 | 0.87 | GNAI3 (0.80) | GNAI3GNAO1GNAI1EPHX1SMN1; SMN2 | |
| SCHEMBL19750263 | 0.87 | GNAI3 (0.80) | GNAI3GNAO1GNAI1EPHX1SMN1; SMN2 | |
| SCHEMBL22628361 | 0.87 | GNAI3 (0.80) | GNAI3GNAO1GNAI1EPHX1SMN1; SMN2 | |
| SCHEMBL10444151 | 0.85 | KCNH2 (0.52) | GNAI3GNAO1GNAI1KCNH2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080085884-A1 | Melanin Concentrating Hormone Receptor-1 Antagonist Pyridinones | PFIZER INC | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085884-A1 | Melanin Concentrating Hormone Receptor-1 Antagonist Pyridinones | MCHR1, MCHR2, MC1R | GNAI3 1602/4885GNAO1 854/4885GNAI1 935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.