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GNAI3

Guanine nucleotide-binding protein G(i) subunit alpha-3 · P08754 · GNAI3 on Sugi Atlas →

36,544 patent compounds predicted against GNAI3, 16,137 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Hydrochloric Acid Hydrochloric Acid (SCHEMBL851007) 0.53 12/20
SCHEMBL1070277 SCHEMBL1070277 0.81 11/20
SCHEMBL293828 SCHEMBL293828 0.50 11/20
SCHEMBL465210 SCHEMBL465210 0.50 11/20
SCHEMBL465189 SCHEMBL465189 0.49 11/20
SCHEMBL595977 SCHEMBL595977 0.92 9/20
SCHEMBL768398 SCHEMBL768398 0.79 9/20
SCHEMBL1044731 SCHEMBL1044731 0.79 9/20
SCHEMBL1045855 SCHEMBL1045855 0.79 9/20
SCHEMBL764605 SCHEMBL764605 0.74 9/20
SCHEMBL151361 SCHEMBL151361 0.68 9/20
SCHEMBL249052 SCHEMBL249052 0.68 9/20
N-(Decanoyl)Pyrrolidine N-(Decanoyl)Pyrrolidine (SCHEMBL692598) 0.68 9/20
SCHEMBL754482 SCHEMBL754482 0.67 9/20
SCHEMBL693510 SCHEMBL693510 0.60 9/20
SCHEMBL11080 SCHEMBL11080 0.55 9/20
SCHEMBL881484 SCHEMBL881484 0.54 9/20
SCHEMBL337723 SCHEMBL337723 0.52 9/20
SCHEMBL293140 SCHEMBL293140 0.51 9/20
SCHEMBL764586 SCHEMBL764586 0.51 9/20

Clinical trials — most relevant to GNAI3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell. PHASE4UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus PHASE3UNKNOWN
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
Setmelanotide to Treat Obesity in a Patient With Pseudohypoparathyroidism Type 1a (PHP1a) PHASE2NOT_YET_RECRUITING
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old PHASE2ACTIVE_NOT_RECRUITING
PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome PHASE1/PHASE2COMPLETED
Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing nanCOMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein nanCOMPLETED
Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor. nanUNKNOWN
NGLY1 Natural History nanCOMPLETED
Histamine Responsiveness in McCune-Albright Syndrome nanCOMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus nanUNKNOWN
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity nanNOT_YET_RECRUITING
Thrombin Regulated Platelet Activation nanCOMPLETED
Multicenter Phenotype-Genotype Analysis of Vascular Stains to Optimize Treatment Utilizing Optical Coherence Tomography nanACTIVE_NOT_RECRUITING
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Genetic Characterization of Parkinson's Disease nanCOMPLETED
ADRB3, ROCK2 and GEF Levels in Overactive Bladder Patients nanCOMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA nanRECRUITING
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo) nanWITHDRAWN
Use of miRNAs in Growth Hormone Deficiency (GHD) nanUNKNOWN
GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM) nanCOMPLETED
GNAO1 Natural History Study nanUNKNOWN
Inherited Reproductive Disorders nanRECRUITING
Non Motor Symptoms in Glucocerebrosidase-related Parkinson's Disease nanENROLLING_BY_INVITATION
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients nanNOT_YET_RECRUITING
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome nanACTIVE_NOT_RECRUITING
A Phase I Trial of AVN944, an IMPDH Inhibitor, in Adults With Advanced Stage Solid Tumors nanWITHDRAWN
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a GNAI3 binder may also engage these)

ProteinNameSimilarity
Q60397 — 1.000 Q60397 →
Q9DC51 — 1.000 Q9DC51 →
P08753 — 1.000 P08753 →
Q5RAD4 — 1.000 Q5RAD4 →
GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-1 1.000 landscape →
GNAI2 Guanine nucleotide-binding protein G(i) subunit alpha-2 1.000 landscape →
P38402 — 1.000 P38402 →
P38403 — 1.000 P38403 →
P08752 — 1.000 P08752 →
P51877 — 1.000 P51877 →
P51876 — 1.000 P51876 →
P87383 — 1.000 P87383 →
P30683 — 1.000 P30683 →
P38401 — 1.000 P38401 →
P87032 — 1.000 P87032 →
Q4R592 — 1.000 Q4R592 →
P30682 — 1.000 P30682 →
P50146 — 1.000 P50146 →
O13055 — 1.000 O13055 →
Q00743 — 1.000 Q00743 →
P0C7Q4 — 1.000 P0C7Q4 →
P38400 — 1.000 P38400 →
P27044 — 1.000 P27044 →
P63097 — 1.000 P63097 →
B2RSH2 — 1.000 B2RSH2 →
P10825 — 1.000 P10825 →
P16378 — 1.000 P16378 →
P27045 — 1.000 P27045 →
P50147 — 1.000 P50147 →
GNAO1 Guanine nucleotide-binding protein G(o) subunit alpha 1.000 landscape →