Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14327220 | 0.87 | ALDH1A1 (0.31) | ALDH1A1KDM4EMAPK1HPGDHTT | |
| SCHEMBL14225503 | 0.79 | KDM4E (0.42) | ALDH1A1KDM4ENPC1POLBGAA | |
| SCHEMBL14239801 | 0.76 | ALDH1A1 (0.35) | CYP1A2CYP2C19ALDH1A1HSD17B10KDM4E | |
| SCHEMBL2111888 | 0.71 | ALDH1A1 (0.44) | CYP1A2CYP2C19ALDH1A1HSD17B10KDM4E | |
| SCHEMBL2825455 | 0.70 | HCAR2 (0.38) | ALDH1A1HSD17B10KDM4ELMNAMAPK1 | |
| SCHEMBL13721978 | 0.69 | SMN1; SMN2 (0.38) | CYP1A2ALDH1A1HSD17B10KDM4EGAA | |
| SCHEMBL12888807 | 0.68 | ALDH1A1 (0.41) | CYP1A2CYP2C19ALDH1A1HSD17B10KDM4E | |
| SCHEMBL3433839 | 0.67 | ALDH1A1 (0.35) | CYP1A2CYP2C19ALDH1A1HSD17B10KDM4E | |
| SCHEMBL13174401 | 0.66 | CYP3A4 (0.33) | CYP1A2ALDH1A1HSD17B10KDM4EMAPK1 | |
| SCHEMBL22746519 | 0.66 | ALDH1A1 (0.43) | CYP1A2CYP2C19ALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653126-B2 | Imidazole derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-02-18 | — | — | US | disclosed |
| US-8653126-B2 | Imidazole derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-02-18 | — | — | US | disclosed |
| US-20120316170-A1 | Imidazole Derivative | DAIICHI SANKYO COMPANY LIMITED (JP) | 2012-12-13 | — | — | US | disclosed |
| US-20120316170-A1 | Imidazole Derivative | DAIICHI SANKYO COMPANY LIMITED (JP) | 2012-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316170-A1 | Imidazole Derivative | S1PR2, S1PR1, SPHK2 | CYP1A2 1239/4885CYP2C19 380/4885ALDH1A1 1568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.