Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | BMP1 | P13497 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230189 | 0.95 | CA1 (0.48) | CNR2BMP1CA1POLBSMN1; SMN2 | |
| SCHEMBL14229874 | 0.93 | CNR2 (0.45) | CNR2BMP1CA1CA12CA9 | |
| SCHEMBL14229131 | 0.91 | FAAH (0.48) | CNR2CA2FAAH | |
| SCHEMBL14228922 | 0.91 | CNR2 (0.47) | CNR2BMP1CA1POLBSMN1; SMN2 | |
| SCHEMBL8910789 | 0.91 | CNR2 (0.55) | CNR2BMP1CA1S1PR2S1PR1 | |
| SCHEMBL14228898 | 0.90 | CA1 (0.40) | CNR2BMP1CA1POLBSMN1; SMN2 | |
| SCHEMBL14228923 | 0.89 | CA1 (0.46) | CNR2BMP1CA1CA12CA9 | |
| SCHEMBL14229362 | 0.87 | CA1 (0.46) | CNR2CA1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL6546815 | 0.87 | CNR2 (0.42) | CNR2BMP1CA1POLBSMN1; SMN2 | |
| SCHEMBL14229917 | 0.87 | CNR2 (0.45) | CNR2CA1CA12CA2CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |