Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | BMP1 | P13497 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | CA7 | P43166 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.31 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.31 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.31 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229101 | 0.96 | CNR2 (0.39) | CA1CA12CA2CA14CNR2 | |
| SCHEMBL14230189 | 0.88 | CA1 (0.48) | CA1CA12CA2CA14CNR2 | |
| SCHEMBL14228923 | 0.86 | CA1 (0.46) | CA1CA12CA2CA14CNR2 | |
| SCHEMBL14229019 | 0.84 | CNR2 (0.33) | CNR2BMP1 | |
| SCHEMBL14229917 | 0.84 | CNR2 (0.45) | CA1CA12CA2CA14CNR2 | |
| SCHEMBL14229342 | 0.84 | CNR2 (0.45) | CA1CA12CA2CA14CNR2 | |
| SCHEMBL14229358 | 0.84 | CA1 (0.48) | CA1CA12CA2CA14CNR2 | |
| SCHEMBL14229012 | 0.83 | CNR2 (0.46) | CA1CA12CA2CA14CNR2 | |
| SCHEMBL14229874 | 0.81 | CNR2 (0.45) | CA1CA12CA2CA14CNR2 | |
| SCHEMBL27905197 | 0.81 | CA1 (0.50) | CA1CA12CA2CA14CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |