Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.38 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230055 | 0.92 | EPHX2 (0.42) | EPHX2MEN1FAAHMAPK1KMT2A | |
| SCHEMBL14229902 | 0.89 | EPHX2 (0.48) | EPHX2LMNAMEN1FAAHMAPK1 | |
| SCHEMBL14229463 | 0.89 | EPHX2 (0.48) | EPHX2 | |
| SCHEMBL14229257 | 0.85 | EPHX2 (0.47) | EPHX2MEN1KMT2ACES2CES1 | |
| SCHEMBL14229927 | 0.84 | EPHX2 (0.42) | EPHX2 | |
| SCHEMBL21287951 | 0.84 | EPHX2 (0.49) | EPHX2LMNAMEN1FAAHMAPK1 | |
| SCHEMBL3370091 | 0.82 | EPHX2 (0.51) | EPHX2KDM5APHF8KDM4C | |
| SCHEMBL14229536 | 0.81 | EPHX2 (0.40) | EPHX2MAPK1KDM5AKDM4C | |
| SCHEMBL14201131 | 0.81 | EPHX2 (0.40) | EPHX2KDM5APHF8KDM4C | |
| SCHEMBL14229461 | 0.80 | EPHX2 (0.46) | EPHX2MEN1KMT2ACES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |