Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229927 | 0.95 | EPHX2 (0.42) | EPHX2FFAR1FFAR4ACE2GPR84 | |
| SCHEMBL3370091 | 0.93 | EPHX2 (0.51) | EPHX2FFAR1FFAR4ACE2GPR84 | |
| SCHEMBL14229902 | 0.93 | EPHX2 (0.48) | EPHX2 | |
| SCHEMBL14229082 | 0.89 | EPHX2 (0.50) | EPHX2 | |
| SCHEMBL14229536 | 0.86 | EPHX2 (0.40) | EPHX2CA1TP53 | |
| SCHEMBL14229257 | 0.82 | EPHX2 (0.47) | EPHX2GPR84 | |
| SCHEMBL14200985 | 0.82 | GPR84 (0.40) | EPHX2FFAR1FFAR4ACE2GPR84 | |
| SCHEMBL14230055 | 0.82 | EPHX2 (0.42) | EPHX2CA1TP53 | |
| SCHEMBL14230058 | 0.81 | CA2 (0.42) | EPHX2FFAR4ACE2CA1TP53 | |
| SCHEMBL14229461 | 0.81 | EPHX2 (0.46) | EPHX2FFAR1FFAR4GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |