Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 11/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229158 | 0.91 | CETP (0.47) | CETPGRM2HDAC8TRPM8GPR139 | |
| SCHEMBL14230194 | 0.90 | HDAC8 (0.43) | CETPGRM2HDAC8TRPM8GPR139 | |
| SCHEMBL14229030 | 0.89 | CETP (0.49) | CETPGRM2HDAC8TRPM8GPR139 | |
| SCHEMBL14229529 | 0.87 | CETP (0.46) | CETPGRM2HDAC8TRPM8GPR139 | |
| SCHEMBL14200475 | 0.86 | CETP (0.46) | CETPGRM2HDAC8 | |
| SCHEMBL23060416 | 0.84 | GRM2 (0.46) | CETPGRM2HDAC8 | |
| SCHEMBL14228934 | 0.84 | CETP (0.45) | CETPGRM2HDAC8GPR139 | |
| SCHEMBL14200463 | 0.80 | CETP (0.48) | CETPGRM2HDAC8 | |
| SCHEMBL14229241 | 0.79 | TP53 (0.49) | CETPGRM2 | |
| SCHEMBL14228932 | 0.79 | TP53 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |