Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 16/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200463 | 0.91 | CETP (0.48) | CETPHDAC8GRM2 | |
| SCHEMBL14200459 | 0.91 | HDAC8 (0.45) | CETPHDAC8GRM2 | |
| SCHEMBL14200462 | 0.89 | CETP (0.50) | CETPHDAC8GRM2 | |
| SCHEMBL14229141 | 0.86 | CETP (0.44) | CETPHDAC8GRM2 | |
| SCHEMBL14200473 | 0.86 | CETP (0.47) | CETPHDAC8GRM2 | |
| SCHEMBL14200474 | 0.83 | CETP (0.46) | CETPHDAC8GRM2 | |
| SCHEMBL14200452 | 0.81 | SIGMAR1 (0.37) | CETPHDAC8 | |
| SCHEMBL14200465 | 0.79 | HPGD (0.44) | HDAC8 | |
| SCHEMBL14200516 | 0.79 | CETP (0.45) | CETPHDAC8GRM2 | |
| SCHEMBL14200440 | 0.78 | ALDH1A1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |