Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14229205 | 0.97 | HTT (0.43) | HTTNCOA1SMN1; SMN2NCOA3LMNA | |
| SCHEMBL14200729 | 0.90 | HTT (0.39) | HTTNCOA1SMN1; SMN2NCOA3LMNA | |
| SCHEMBL14229050 | 0.88 | HTT (0.44) | HTTNCOA1SMN1; SMN2NCOA3LMNA | |
| SCHEMBL14229052 | 0.88 | HTT (0.44) | HTTNCOA1SMN1; SMN2NCOA3LMNA | |
| SCHEMBL14229051 | 0.85 | HTT (0.42) | HTTNCOA1SMN1; SMN2NCOA3LMNA | |
| SCHEMBL14228956 | 0.85 | HTT (0.42) | HTTNCOA1SMN1; SMN2NCOA3LMNA | |
| SCHEMBL14200731 | 0.80 | HTT (0.36) | HTTSMN1; SMN2AGTR1AGTR2NPC1 | |
| SCHEMBL14200674 | 0.79 | HTT (0.38) | HTTNCOA1SMN1; SMN2NCOA3LMNA | |
| SCHEMBL14200677 | 0.79 | HTT (0.38) | HTTNCOA1SMN1; SMN2NCOA3LMNA | |
| SCHEMBL14228946 | 0.77 | MLYCD (0.44) | HTTNCOA1SMN1; SMN2NCOA3AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |