Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CETP | P11597 | 2/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14230176 | 0.99 | MAPK1 (0.53) | MEN1ALDH1A1LMNATHRATHRB | |
| SCHEMBL14229263 | 0.94 | MAPK1 (0.54) | MEN1ALDH1A1LMNATHRATHRB | |
| SCHEMBL14229281 | 0.90 | MAPK1 (0.55) | MEN1ALDH1A1LMNATHRATHRB | |
| SCHEMBL14229427 | 0.87 | CETP (0.50) | MEN1ALDH1A1LMNATHRATHRB | |
| SCHEMBL14229928 | 0.86 | CETP (0.49) | MEN1ALDH1A1LMNATHRATHRB | |
| SCHEMBL14229423 | 0.86 | MAPK1 (0.51) | MEN1ALDH1A1LMNATHRATHRB | |
| SCHEMBL14229246 | 0.85 | MAPK1 (0.57) | MEN1ALDH1A1LMNATHRATHRB | |
| SCHEMBL14201053 | 0.85 | SMN1; SMN2 (0.50) | MEN1ALDH1A1KMT2ACETPP2RX7 | |
| SCHEMBL14229465 | 0.84 | MAPK1 (0.50) | MEN1ALDH1A1LMNATHRATHRB | |
| SCHEMBL14201051 | 0.83 | SMN1; SMN2 (0.51) | MEN1ALDH1A1KMT2ACETPP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |